Development of Conjugate Addition of Lithium Dialkylcuprates to Thiochromones: Synthesis of 2-Alkylthiochroman-4-ones and Additional Synthetic Applications

Lithium dialkylcuprates undergo conjugate addition to thiochromones to afford 2-alkylthiochroman-4-ones in good yields.This approach provide an efficient and general synthetic approach to privileged sulfur-containing structural motifs and valuable precursors for many pharmaceuticals, starting from common substrates-thiochromones.Good yields colliri

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Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance.

BACKGROUND:Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs).Many of the OSCCs present at late stages with an exceptionally poor prognosis.A probable limitation in management of patients with OSCC lies in the insufficient knowledge utopia hoodie brown pertaining to the linkage between copy number alterations in OSCC and

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